Farnesyl Transferase
Ftase
Farnesyl transferase is a zinc-dependent enzyme that catalyzes the attachment of a farnesyl lipid group to the sulfur atom of a cysteine residue of numerous proteins involved in cell signaling including the oncogenic H-Ras protein. Farnesyl transferase regulates the activation of Ras protein and consequently affects intracellular signal transduction, cell growth and proliferation.
Farnesyl transferase is an essential enzyme at downstream of mevalonate (MVA) pathway. Farnesyl transferase catalyzes the farnesylmoieties of farnesyl pyrophosphate (FPP) coupled to Ras protein, which is dependent on farnesylation anchoring itself in membrane for its activity. Farnesyl transferase inhibitors are small-molecule inhibitors that selectively inhibit farnesylation of a number of intracellular substrate proteins such as Ras. Farnesyl transferase inhibitors represent a new class of agents that target signal transduction pathways responsible for the proliferation and survival of diverse malignant cell types.
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Farnesyl Transferase Related Products (97)
Related Products (97)
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Antibodies (1)
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Andrastin C
0 ImagesCat. No.: HY-N9604CAS No.: 174232-44-1Andrastin B is a protein farnesyltransferase inhibitor. Andrastin B has a common androstane skeleton.
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XR 3054
0 ImagesCat. No.: HY-125669CAS No.: 247090-97-7XR 3054 is an inhibitor for Farnesyl Transferase, that inhibits farnesylation of CAAX recognition peptide with IC50 of 50 μM. XR 3054 suppresses the farnesylation of p21 ras and activation of MAP kinase. XR 3054 inhibits the proliferation of prostate cancer cell and colon cancer cell, with IC50 of 8.8-21.4 μM.
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Olpadronic acid (Standard)
0 ImagesCat. No.: HY-106431RCAS No.: 63132-39-8Synonyms: Olpadronate (Standard); OLP (Standard)Olpadronic acid (Standard) is the analytical standard of Olpadronic acid. This product is intended for research and analytical applications. Olpadronic acid is an orally active amino-bisphosphonate and inhibits bone resorption. Olpadronic acid prevents bone destruction and tumor growth in the skeletal prostate cancer mouse model. Olpadronic acid can be used for research of osteoporosis, malignancies and rheumatoid arthritis.
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FTI-2628
0 ImagesCat. No.: HY-183458CAS No.: 655234-81-4FTI-2628 is an antimalarial agent and a farnesyl transferase inhibitor, with an IC50 of 41.7 nM against TbPET. FTI-2628 attenuates glucose-stimulated insulin secretion. FTI-2628 exhibits antimalarial activity against Trypanosoma brucei.
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L-778123 dihydrochloride
0 ImagesCat. No.: HY-16273BCAS No.: 183499-56-1L-778123 dihydrochloride is a dual FPTase and GGPTase-I inhibitor, with IC50s of 2 nM and 98 nM, respectively.
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Chaetomellic acid A
0 ImagesCat. No.: HY-134579CAS No.: 148796-51-4Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of farnesyl-protein transferase. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice.
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E5700
0 ImagesCat. No.: HY-123746CAS No.: 332132-39-5E5700 is an orally active squalene synthase inhibitor, antimalarial agent and antifungal agent with an IC50 of 0.49 nM (without PPi) against squalene synthase from T. cruzi epimastigotes. E5700 shows antiparasitic activities against Trypanosoma cruzi. E5700 inhibits the growth and alters the lipid prolife and the ultrastructure of a multiple agent-resistant C. tropicalis strain. E5700 is a potent and selective inhibitor of the growth of Leishmania amazonensis.
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Andrastin D
0 ImagesCat. No.: HY-N13876CAS No.: 184432-08-4Andrastin D is a protein farnesyltransferase inhibitor. Andrastin D has a common androstane skeleton.
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Gerfelin
0 ImagesCat. No.: HY-124723CAS No.: 627545-07-7Gerfelin inhibits geranylgeranyl diphosphate synthase (GGPP synthase) activity with an IC50 of 3.5 μg/mL.
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FTI-277 TFA
0 ImagesCat. No.: HY-110038CAS No.: 1217447-06-7FTI-277 TFA is a farnesyltransferase (FTase) inhibitor. FTI-277 TFA inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 TFA activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 TFA activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 TFA can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification.
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BMS-186511
0 ImagesCat. No.: HY-120614CAS No.: 167467-53-0BMS-186511 is a farnesyltransferase (FT) inhibitor and shows anticancer activity.
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Kurasoin B
0 ImagesCat. No.: HY-122469CAS No.: 193696-42-3Kurasoin B is a protein farnesyltransferase inhibitor (IC50: 58.7 μM). Kurasoin B can be produced by Paecilomyces sp. FO-3684.
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10'-Desmethoxystreptonigrin
0 ImagesCat. No.: HY-137139CAS No.: 136803-89-910'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD50 is 8.8 mg/kg).
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Aminobutane bisphosphonate
0 ImagesCat. No.: HY-182516CAS No.: 32545-60-1Aminobutane bisphosphonate is a Trypanosoma cruzi farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC50 of 30.77 μM against Trypanosoma cruzi. Aminobutane bisphosphonate inhibits proliferation of intracellular amastigote Trypanosoma cruzi and lacks activity against non-infective epimastigote forms. Aminobutane bisphosphonate reduces osteoclastic bone resorption, osteoid surface extent, and osteoclast number per mm of bone surface. Aminobutane bisphosphonate can be used for the research of american trypanosomiasis (chagas' disease) and immobilization-related bone loss.
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Prenyl-IN-1
0 ImagesCat. No.: HY-U00327CAS No.: 360561-53-1Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
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(Rac)-CP-609754
0 ImagesCat. No.: HY-U00401CAS No.: 439153-64-7Synonyms: (Rac)-LNK-754; (Rac)-OSI-754(Rac)-CP-609754 is the racemate of CP-609754. CP-609754 is a farnesyltransferase inhibitor, used for the treatment of cancer and Alzheimer's disease.
